It is getting harder and harder to achieve any advantage with White pieces in the main lines. Black seems to hold their own in most of the popular openings. Modern chess players of all levels have an access to the strongest engines, and they use them for opening preparation. Usually, your best chance against such players is to play something they don’t know. This way you avoid playing against the machine moves in the beginning. This approach made the Larsen’s Opening (1.b3) quite enticing for White. In recent years, many strong grandmasters started using it with great success.