One of the main weapons against 1.e4 is the French Defense (1…e6) and a very popular variation of this defense is the so-called Winawer Variation which arises after the moves: 1.e4 e6 2.d4 d5 3.Nc3 Bb4 4.e5
The positions arising from this variation usually yield a thick central pawn structure with white pawns on c2-c3-d4-e5 and black pawns on e6-d5-c5 or c4.